Year: 2025
Authors: Roger Prades, Meritxell Teixidó, Benjamí Oller Salvia
Journal: ACS Publications
Abstract
The pharmacological treatment of central nervous system diseases faces significant challenges due to the presence of the blood−brain barrier (BBB). This barrier naturally protects the brain and prevents therapeutics from reaching their targets efficiently. However, the BBB allows the passage of nutrients and other molecules that guarantee brain homeostasis through selective transport mechanisms present at the BBB. These mechanisms provide an opportunity for delivering therapeutic agents into the central nervous system using peptides for brain delivery and other BBB-penetrating technologies. Here we review the progress of peptides for brain delivery from 2015 until 2025. We highlight the most utilized peptides and describe trends in strategies to develop new delivery approaches and enhance their transport efficiency. Additionally, we compare them with other brain delivery technologies and emphasize the progress of peptides for brain delivery toward clinical translation.
